BDBM516848 US11104664, Compound P-19

SMILES CCN([C@H]1CC[C@@H](CC1)N1CC(C1)OC)c1c(CC)c(cc2n(C)ncc12)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=RMCZYCXICUWIDC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 516848   

LigandPNGBDBM516848(US11104664, Compound P-19)
Affinity DataIC50: 45nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-Aldrich,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM516848(US11104664, Compound P-19)
Affinity DataIC50: 45nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed