BDBM516574 US11053243, Example 169::tert-butyl {(1R)-2-[(2S)-2-({4- [5-({[(2S)-1-{(2R)-2-[(tert- butoxycarbonyl)amino]-2- phenylacetyl}pyrrolidin-2- yl]carbonyl}amino)-3-(3- methylphenyl)-1H-indol-2- yl]phenyl}carbamoyl)pyrrolidin- 1-yl]-2-oxo-1- phenylethyl}carbamate

SMILES Cc1cccc(c1)-c1c([nH]c2ccc(NC(=O)[C@@H]3CCCN3C(=O)[C@H](NC(=O)OC(C)(C)C)c3ccccc3)cc12)-c1ccc(NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)OC(C)(C)C)c2ccccc2)cc1

InChI Key InChIKey=XUIIRTRGXIYKBA-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 516574   

TargetGenome polyprotein(HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM516574(US11053243, Example 169 | tert-butyl {(1R)-2-[(2S)...)
Affinity DataEC50:  0.00400nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent