BDBM5162 (2E)-2-({4-[(2E)-2-cyano-2-[(3,4-dihydroxyphenyl)methylidene]acetyl]piperazin-1-yl}carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile::CHEMBL358494::Dimeric Tyrphostin 15

SMILES Oc1ccc(\C=C(/C#N)C(=O)N2CCN(CC2)C(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O

InChI Key InChIKey=LGNJLNMJHWXSGQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5162   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM5162(CHEMBL358494 | (2E)-2-({4-[(2E)-2-cyano-2-[(3,4-di...)
Affinity DataIC50: 4.00E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed
TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM5162(CHEMBL358494 | (2E)-2-({4-[(2E)-2-cyano-2-[(3,4-di...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against dynamin1 GTPase expressed in sheep brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed