BDBM516 CHEMBL62658::N-[2,6-bis(propan-2-yl)phenyl]-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2,4-dioxo-6-phenylhexanamide::NSC 647086

SMILES CC(C)c1cccc(C(C)C)c1NC(=O)C(=O)CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O

InChI Key InChIKey=DJDZPJCHQJIERW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 516   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Institutes of Health

LigandPNGBDBM516(N-[2,6-bis(propan-2-yl)phenyl]-6-(4-hydroxy-2-oxo-...)
Affinity DataIC50: 3.10E+4nMpH: 6.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2004
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM516(N-[2,6-bis(propan-2-yl)phenyl]-6-(4-hydroxy-2-oxo-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM516(N-[2,6-bis(propan-2-yl)phenyl]-6-(4-hydroxy-2-oxo-...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM516(N-[2,6-bis(propan-2-yl)phenyl]-6-(4-hydroxy-2-oxo-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed