BDBM515983 US11053238, Com. EX. 6

SMILES CC1(C)CCCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F

InChI Key InChIKey=XDEIHTNJRRVHEQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 515983   

TargetCyclin-A2 [177-432]/Cyclin-dependent kinase 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515983(US11053238, Com. EX. 6)
Affinity DataIC50: 40nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515983(US11053238, Com. EX. 6)
Affinity DataIC50: 7nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/6(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515983(US11053238, Com. EX. 6)
Affinity DataIC50: 14nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent