BDBM515909 2-(5-Chloro-2- (cyclopropylmethyl)- 3-((5-methoxy-3,4- dihydro-2(1H)- isoquinolinyl) carbonyl)-7-methyl- 1H-indol-1-yl)-N- methyl-N-(1-(2- propenoyl)-3- azetidinyl)acetamide::US11053226, Example 4-4

SMILES COc1cccc2CN(CCc12)C(=O)c1c(CC2CC2)n(CC(=O)N(C)C2CN(C2)C(=O)C=C)c2c(C)cc(Cl)cc12

InChI Key InChIKey=IYFNZTVIFQFNAI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 515909   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM515909(US11053226, Example 4-4 | 2-(5-Chloro-2- (cyclopro...)
Affinity DataIC50: 100nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
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