BDBM515895 2-(5-Chloro-2- cyclopropyl-3- ((5-methoxy-3,4- dihydro-2,6- naphthyridin- 2(1H)- yl)carbonyl)-7- methyl-1H-indol- 1-yl)-N-(1-(2- propenoyl)-3- azetidinyl) acetamide::US11053226, Example 1-4

SMILES COc1nccc2CN(CCc12)C(=O)c1c(C2CC2)n(CC(=O)NC2CN(C2)C(=O)C=C)c2c(C)cc(Cl)cc12

InChI Key InChIKey=VVWKWJVLNNPBLF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 515895   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM515895(US11053226, Example 1-4 | 2-(5-Chloro-2- cycloprop...)
Affinity DataIC50: 270nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM515895(US11053226, Example 1-4 | 2-(5-Chloro-2- cycloprop...)
Affinity DataIC50: 80nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM515895(US11053226, Example 1-4 | 2-(5-Chloro-2- cycloprop...)
Affinity DataIC50: 10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent