BDBM5158 (2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamido]butyl}-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide::Dimeric Tyrphostin 11

SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cc(OC)c(O)c(c2)[N+]([O-])=O)\C#N)cc(c1O)[N+]([O-])=O

InChI Key InChIKey=KELGROZXKWYKRA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5158   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM5158((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(4-hydroxy-3-met...)
Affinity DataIC50: 1.12E+5nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed