BDBM515525 (7-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyrimidin-3-yl]methyl}-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl)(3-fluoro-6-methoxypyridin-2-yl)methanone::US11098063, Example 15

SMILES COc1ccc(F)c(n1)C(=O)N1C2COCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)C2

InChI Key InChIKey=IDQHHCOWPCFYIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515525   

TargetPotassium channel subfamily K member 9(Human)
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US Patent
LigandPNGBDBM515525(US11098063, Example 15 | (7-{[2-(4-Chlorophenyl)im...)
Affinity DataIC50: 19nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetPotassium channel subfamily K member 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515525(US11098063, Example 15 | (7-{[2-(4-Chlorophenyl)im...)
Affinity DataIC50: 1.10E+3nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent