BDBM515510 (3-Chloro-6-methoxypyridin-2-yl)(5-{[2-(4-isopropylphenyl)imidazo[1,2-a]pyrimidin-3-yl]methyl}-2,5-diazabicyclo[2.2.2]oct-2-yl)methanone (Enantiomer 2)::US11098063, Example 26::US11098063, Example 69

SMILES COc1ccc(Cl)c(n1)C(=O)N1CC2CCC1CN2Cc1c(nc2ncccn12)-c1ccc(cc1)C(C)C

InChI Key InChIKey=DUJLETLIURKNQV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 515510   

TargetPotassium channel subfamily K member 9(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515510(US11098063, Example 69 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 16nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetPotassium channel subfamily K member 9(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515510(US11098063, Example 69 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 22nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetPotassium channel subfamily K member 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515510(US11098063, Example 69 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 31.2nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetPotassium channel subfamily K member 9(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515510(US11098063, Example 69 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 140nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetPotassium channel subfamily K member 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515510(US11098063, Example 69 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 1.40E+3nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetPotassium channel subfamily K member 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515510(US11098063, Example 69 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 2.80E+3nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent