BDBM515376 (13E,14E,22R,24R)-12-amino-35- fluoro-24-hydroxy-4-oxa-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine- 2(1,2)-pyrrolidine-3(1,2)- benzocyclooctanephane-8-one::US11098060, Example 36

SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1C[C@@H](O)CN31

InChI Key InChIKey=ZSZVIEKAJWEOIG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 515376   

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515376(US11098060, Example 36 | (13E,14E,22R,24R)-12-amin...)
Affinity DataIC50: 8.16nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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