BDBM515375 (13E,14E,22R,24S)-12-amino-24,35,6,6- tetrafluoro-4-oxa-8-aza-1(5,3)- pyrazol[1,5-a]pyrimidine-3(3,2)- pyridine-2(1,2)- pyrrolidylcyclononanephane-9-one::US11098060, Example 35

SMILES Nc1nn2ccc3nc2c1C(=O)NCC(F)(F)COc1ncc(F)cc1[C@H]1C[C@H](F)CN31

InChI Key InChIKey=HVVZYOAZZWHYBG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515375   

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515375(US11098060, Example 35 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 0.360nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515375(US11098060, Example 35 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 1.36nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent