BDBM515373 (R,13E,14E)-12-amino-35-fluoro- 4-oxa-7-aza-1(5,3)- pyrazo[1,5-a]pyrimidine- 3(3,2)-pyridine-2(1,2)- pyrrolidylcyclooctanephane- 8-one::US11098060, Example 33

SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1[C@H]1CCCN31

InChI Key InChIKey=XECPWXZVGRSTIL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 515373   

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515373(US11098060, Example 33 | (R,13E,14E)-12-amino-35-f...)
Affinity DataIC50: 1.46nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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