BDBM515372 (13E,14E,22R,5S)-12-amino-35- fluoro-5-methyl-4-oxa-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine- (1,2)-pyrrolidine-3(1,2)- benzocyclooctanephane-8-one::US11098060, Example 32

SMILES C[C@H]1CNC(=O)c2c(N)nn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2O1

InChI Key InChIKey=CXEWEVLISPQKMP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515372   

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515372(US11098060, Example 32 | (13E,14E,22R,5S)-12-amino...)
Affinity DataIC50: 0.430nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515372(US11098060, Example 32 | (13E,14E,22R,5S)-12-amino...)
Affinity DataIC50: 1.28nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent