BDBM515366 (13E,14E)-12-amino-35-fluoro-31,32-dihydro-7- aza-1(5,3)-pyrazolo[1,5-a]pyrimidine-3(3,1)- pyridine-2(1,2)-pyrrolidylcyclooctanephane- 32,8-dione::US11098060, Example 24

SMILES Nc1nn2ccc3nc2c1C(=O)NCCCn1cc(F)cc(C2CCCN32)c1=O

InChI Key InChIKey=QJDKWPXISXYHFX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515366   

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515366(US11098060, Example 24 | (13E,14E)-12-amino-35-flu...)
Affinity DataIC50: 0.850nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515366(US11098060, Example 24 | (13E,14E)-12-amino-35-flu...)
Affinity DataIC50: 16nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent