BDBM515361 (13E,14E,22R,24S,6R)-12-amino-24, 35-difluoro-6-methyl-4-oxa-7- aza-1(5,3)-pyrazolo[1,5-a] pyrimidine-3(3,2)-pyridine-2(1,2)- pyrrolidylcyclooctanephane-8-one::US11098060, Example 19

SMILES C[C@@H]1COc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2

InChI Key InChIKey=YPMAHALRHIGYCE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515361   

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515361(US11098060, Example 19 | (13E,14E,22R,24S,6R)-12-a...)
Affinity DataIC50: 0.380nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515361(US11098060, Example 19 | (13E,14E,22R,24S,6R)-12-a...)
Affinity DataIC50: 0.730nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent