BDBM515355 (13E,14E, 22R,24R)-12-amino-24,35- difluoro-4-oxa-8-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine-3(3,2)-pyridine-2 (1,2)-pyrrolidylcyclononanephane-9-one::US11098060, Example 13

SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1C1C[C@@H](F)CN31

InChI Key InChIKey=HOXCAURHIUIQJM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515355   

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515355(US11098060, Example 13 | (13E,14E, 22R,24R)-12-ami...)
Affinity DataIC50: 0.640nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515355(US11098060, Example 13 | (13E,14E, 22R,24R)-12-ami...)
Affinity DataIC50: 14.6nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent