BDBM515331 US11110088, Compound Table 1.11::US11110088, Compound Table 1.5

SMILES COc1cc(ccc1C(=O)Nc1ccc(C)cn1)-c1nc([C@H](C)N(C)C(=O)C#CC)n2ccnc(N)c12

InChI Key InChIKey=XNPHXLCYBBQUQK-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 515331   

TargetTyrosine-protein kinase BTK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 4.20nMAssay Description:BTK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.BTK enzyme (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
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TargetEpidermal growth factor receptor(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:EGFR enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.EGFR enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Tec(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 4.5nMAssay Description:TEC enzyme (Millipore #14-801M), is diluted to 2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 12nMAssay Description:TXK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.TXK enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:ITK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.ITK enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 16nMAssay Description:BMX enzyme (Millipore #14-499M), is diluted to 0.5 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 5.10nMAssay Description:BTK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.BTK enzyme (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:EGFR enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.EGFR enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Tec(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 4.60nMAssay Description:TEC enzyme (Millipore #14-801M), is diluted to 2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 5.10nMAssay Description:TXK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.TXK enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:ITK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.ITK enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515331(US11110088, Compound Table 1.11 | US11110088, Comp...)
Affinity DataIC50: 6.80nMAssay Description:BMX enzyme (Millipore #14-499M), is diluted to 0.5 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent