BDBM515326 2-{2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]ethyl}-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-ylcarbonyl)-3,4-dihydroisoquinolin-1(2H)-one::US11098059, Example 30

SMILES OC(CN1CCc2cc(ccc2C1=O)C(=O)N1C2CCC1COC2)[C@@H]1Cc2ccccc2CN1

InChI Key InChIKey=XOMOAMNPYQDKPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515326   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515326(US11098059, Example 30 | 2-{2-hydroxy-2-[(3S)-1,2,...)
Affinity DataIC50: 16.6nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515326(US11098059, Example 30 | 2-{2-hydroxy-2-[(3S)-1,2,...)
Affinity DataIC50: 6.28E+3nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent