BDBM515325 2-{(2R)-2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]ethyl}-4,4-dimethyl-6-(3-oxo-2-azabicyclo[2.2.2]octan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one::US11098059, Example 29

SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)N1C2CCC(CC2)C1=O

InChI Key InChIKey=BRFSSECTMNOADC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515325   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515325(US11098059, Example 29 | 2-{(2R)-2-hydroxy-2-[(3S)...)
Affinity DataIC50: 0.840nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515325(US11098059, Example 29 | 2-{(2R)-2-hydroxy-2-[(3S)...)
Affinity DataIC50: 359nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent