BDBM515324 6-(hexahydro-3,6- epiminofuro[3,2-b]furan- 7-carbonyl)-2-((S)-2- hydroxy-2-((S)-1,2,3,4- tetrahydroisoquinolin-3- yl)ethyl)-4,4-dimethyl- 3,4-dihydroisoquinolin- 1(2H)-one::US11098059, Example 28

SMILES CC1(C)CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2COC3C1COC23

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515324   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515324(US11098059, Example 28 | 6-(hexahydro-3,6- epimino...)
Affinity DataIC50: 34.3nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515324(US11098059, Example 28 | 6-(hexahydro-3,6- epimino...)
Affinity DataIC50: 3.43E+4nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent