BDBM515322 2-((S)-2-hydroxy-2-((S)- 1,2,3,4- tetrahydroisoquinolin-3- yl)ethyl)-6-((1R,3R,5S)- 3-methoxy-8- azabicyclo[3.2.1]octane- 8-carbonyl)-4,4-dimethyl- 3,4-dihydroisoquinolin- 1(2H)-one::US11098059, Example 26

SMILES CO[C@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515322   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515322(US11098059, Example 26 | 2-((S)-2-hydroxy-2-((S)- ...)
Affinity DataIC50: 24.3nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515322(US11098059, Example 26 | 2-((S)-2-hydroxy-2-((S)- ...)
Affinity DataIC50: 1.46E+4nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent