BDBM515307 6'-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-2'-{(2R)-2- hydroxy-2-[(3S)-1,2,3,4- tetrahydroisoquinolin-3- yl]ethyl}-2',3'-dihydro-1'H- spiro[cyclobutane-1,4'- isoquinolin]-1'-one::US11098059, Example 11

SMILES O[C@H](CN1CC2(CCC2)c2cc(ccc2C1=O)-c1ncnn1C1CC1)[C@@H]1Cc2ccccc2CN1

InChI Key InChIKey=SKLDQNBOLVKBJG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515307   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515307(US11098059, Example 11 | 6'-(1-cyclopropyl-1H-1,2,...)
Affinity DataIC50: 0.290nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515307(US11098059, Example 11 | 6'-(1-cyclopropyl-1H-1,2,...)
Affinity DataIC50: 127nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent