BDBM515297 US11098059, Example 1::US11098059, Example 5

SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12

InChI Key InChIKey=NSYXJLZEQPXXPZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 515297   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515297(US11098059, Example 5 | US11098059, Example 1)
Affinity DataIC50: 5.38nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515297(US11098059, Example 5 | US11098059, Example 1)
Affinity DataIC50: 465nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515297(US11098059, Example 5 | US11098059, Example 1)
Affinity DataIC50: 3.74E+3nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515297(US11098059, Example 5 | US11098059, Example 1)
Affinity DataIC50: 1.00E+5nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent