BDBM515021 US11098044, Example 63

SMILES Cc1c[nH]c2ccc(C)c(-c3ccc4nc(NC(=O)[C@@H]5C[C@@H]5F)cn4c3)c12

InChI Key InChIKey=AAQFTGFEIOSNMG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 515021   

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM515021(US11098044, Example 63)
Affinity DataIC50: 10nMAssay Description:c-abl: ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(p-aminoethyl ether)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM515021(US11098044, Example 63)
Affinity DataIC50: 550nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the Adapta technology in ThermoFisher Scientific. This experiment was carried out accor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
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TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM515021(US11098044, Example 63)
Affinity DataIC50: 55nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the Adapta technology in ThermoFisher Scientific. This experiment was carried out accor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent