BDBM514680 (S)-N-(4-methyl-3-(2-morpholino-6- (oxetan-3-ylamino)pyridin-4-yl)phenyl)- 3-(2,2,2-trifluoroethyppyrrolidine-1- carboxamide::US11098031, Example 42

SMILES Cc1ccc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)cc1-c1cc(NC2COC2)nc(c1)N1CCOCC1

InChI Key InChIKey=AIVFNLJHBDQYNK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 514680   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM514680((S)-N-(4-methyl-3-(2-morpholino-6- (oxetan-3-ylami...)
Affinity DataIC50: 10nMAssay Description:Small molecule inhibition of RAF1 kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent