BDBM514652 (S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-morpholinopyridin-4-yl)-4- methylphenyl)-3-(2,2,2- trifluoroethyl)pyrrolidine-1-carboxamide::US11098031, Example 14

SMILES C[C@H](CO)Nc1cc(cc(n1)N1CCOCC1)-c1cc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)ccc1C

InChI Key InChIKey=GZMYLSJUNSCMTD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 514652   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 10nMAssay Description:Small molecule inhibition of RAF1 kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 107nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed