BDBM514531 3,6,6-trimethyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl)-1,3,8- triazaspiro[4.5]decane-2,4- dione::US11096930, Example 10

SMILES CN1C(=O)NC2(CCN(CC2(C)C)c2cc(cc3cncn23)C(F)(F)F)C1=O

InChI Key InChIKey=YOOZUAORCNRVGC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 514531   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514531(3,6,6-trimethyl-8-(7- (trifluoromethyl)imidazo[1,5...)
Affinity DataIC50: 631nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514531(3,6,6-trimethyl-8-(7- (trifluoromethyl)imidazo[1,5...)
Affinity DataIC50: 2.69E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent