BDBM514529 N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino] pyridine-3-carboxamide::US11053216, Compound 19

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)NCCN)-c1cc(Cl)ccc1F

InChI Key InChIKey=OIYYETCFCIAZSC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 514529   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 2.13E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 6.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM514529(N-(2-aminoethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALK5 autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed