BDBM513488 4-(3-ethyl-7-fluoro-2,3-dimethyl-3H-indol-5-yl)-5-fluoro-N-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)pyrimidine-2-amino::US11091476, Example 42

SMILES CCC1(C)C(C)=Nc2c1cc(cc2F)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1F

InChI Key InChIKey=HYCVDTLTXMMBHQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 513488   

TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM513488(4-(3-ethyl-7-fluoro-2,3-dimethyl-3H-indol-5-yl)-5-...)
Affinity DataIC50: 3.68E+3nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM513488(4-(3-ethyl-7-fluoro-2,3-dimethyl-3H-indol-5-yl)-5-...)
Affinity DataIC50: 2.33nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent