BDBM51305 3,5-diphenyl-2-(trifluoromethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one::3,5-diphenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::CHEMBL522946::MLS000850151::SMR000456169::cid_2810970

SMILES c1ccc(cc1)C2=CC(=O)N3C(=N2)C(=C(N3)C(F)(F)F)c4ccccc4

InChI Key InChIKey=OOAHQJLYDSAULT-UHFFFAOYSA-N

Data  5 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 51305   

TargetGlycoprotein 42(HHV-4)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM51305(SMR000456169 | 3,5-diphenyl-2-(trifluoromethyl)pyr...)
Affinity DataIC50: 1.03E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
Target1-deoxy-D-xylulose-5-phosphate synthase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM51305(SMR000456169 | 3,5-diphenyl-2-(trifluoromethyl)pyr...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis cloned 1-deoxy-D-xylulose-5-phosphate synthase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM51305(SMR000456169 | 3,5-diphenyl-2-(trifluoromethyl)pyr...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human recombinant TYK2 JH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM51305(SMR000456169 | 3,5-diphenyl-2-(trifluoromethyl)pyr...)
Affinity DataIC50: 2.50E+4nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM51305(SMR000456169 | 3,5-diphenyl-2-(trifluoromethyl)pyr...)
Affinity DataIC50: 4.70E+4nMAssay Description:Binding affinity to JAK2 JH2 V617F mutant (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)