BDBM511685 5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-((4-isopropylpiperazin-1-yl)methyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzofuran-4-carboxamide::US11059811, Example 5

SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCC(CC3)C(C)C)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC

InChI Key InChIKey=XJENFVOMSPQNNJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 511685   

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM511685(5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2...)
Affinity DataIC50: 1.20nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
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Date in BDB:
1/23/2022
Entry Details
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