BDBM511618 US11059801, Compound dBET26

SMILES COC(=O)C[C@@H]1N=C(c2c(sc(C)c2C(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)-n2c(C)nnc12)c1ccc(Cl)cc1

InChI Key InChIKey=KNHZIKBDHRXJHX-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 511618   

TargetBromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon(Human)
Dana-Farber Cancer Institute

US Patent

LigandBDBM511618(US11059801, Compound dBET26)Copy SMILESCopy InChI

Affinity DataIC50: 282nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/23/2022
Entry Details
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