BDBM511607 US11059801, Compound dBET15

SMILES Cc1nnc2[C@H](CC(=O)NCCCCCCNC(=O)c3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1

InChI Key InChIKey=SYJHORXMXBZSSH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511607   

TargetDNA damage-binding protein 1/Protein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM511607(US11059801, Compound dBET15)
Affinity DataIC50: 40.4nMAssay Description:A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
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LigandPNGBDBM511607(US11059801, Compound dBET15)
Affinity DataIC50: 31nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent