BDBM511484 US11059789, Example 33::US11691950, Example 33

SMILES CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1

InChI Key InChIKey=SDZRYLPROGBZMB-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 511484   

TargetThymocyte selection-associated high mobility group box protein TOX(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 5.52E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 1.24E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 1.58E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 142nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 145nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 4.01E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 5.00E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 3.01E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 4.24E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 5.00E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 81nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 21nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 14nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 103nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 14nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 142nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 145nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 4.01E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 3.01E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 4.24E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 81nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 21nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent