BDBM511481 US11059789, Example 25::US11691950, Example 25

SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1

InChI Key InChIKey=LYJKMVFAIXOQLE-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 511481   

TargetThymocyte selection-associated high mobility group box protein TOX(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 955nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 1.58E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 225nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 173nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 3.85E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 5.00E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 2.14E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 4.09E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 5.00E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 138nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 25nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 17nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 39nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 17nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 955nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 225nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 173nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 3.85E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 4.09E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 138nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 25nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent