BDBM511048 7-((2R,3R,4S,5R)-5-(((2-aminoquinolin-7- yl)oxy)methyl)-3,4-dihydroxy-4- methyltetrahydrofuran-2-yl)-3,7-dihydro- 4H-pyrrolo[2,3-d]pyrimidin-4-one O- methyl oxime::US11078205, Example 32::US11208416, Example 32

SMILES CO\N=c1/[nH]cnc2n(ccc12)[C@@H]1O[C@H](COc2ccc3ccc(N)nc3c2)[C@@](C)(O)[C@H]1O

InChI Key InChIKey=HPBVVJIUOMEVGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511048   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM511048(7-((2R,3R,4S,5R)-5-(((2-aminoquinolin-7- yl)oxy)me...)
Affinity DataIC50: 10nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM511048(7-((2R,3R,4S,5R)-5-(((2-aminoquinolin-7- yl)oxy)me...)
Affinity DataIC50: 10nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent