BDBM510978 1-methyl-6-{[(4s)-6-[1- (2,2-difluoroethyl)-1H- pyrazolo[3,4-b]pyridine-5- amido]spiro[3.3]heptan-2- yl]oxy}-1H-pyrazolo[3,4- b]pyridine-5-carboxamide::US11078197, Example 157::US11673886, Example 157

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cnc5n(CC(F)F)ncc5c4)C3)nc12

InChI Key InChIKey=YTZGIVWFRMPVOU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510978   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510978(1-methyl-6-{[(4s)-6-[1- (2,2-difluoroethyl)-1H- py...)
Affinity DataIC50: 1.09E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510978(1-methyl-6-{[(4s)-6-[1- (2,2-difluoroethyl)-1H- py...)
Affinity DataIC50: 10.9nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent