BDBM510976 5-(4-cyanophenyl)-1- (difluoromethyl)-N-[(4s)- 6-({5-carbamoyl-1-methyl- 1H-pyrazolo[3,4-b]pyridin- 6-yl}oxy)spiro[3.3]heptan- 2-yl]-1H-pyrazole-3- carboxamide::US11078197, Example 155::US11673886, Example 155

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cc(-c5ccc(cc5)C#N)n(n4)C(F)F)C3)nc12

InChI Key InChIKey=RTCCSCOQTTWPNW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510976   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510976(5-(4-cyanophenyl)-1- (difluoromethyl)-N-[(4s)- 6-(...)
Affinity DataIC50: 2.70E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
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TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510976(5-(4-cyanophenyl)-1- (difluoromethyl)-N-[(4s)- 6-(...)
Affinity DataIC50: 2.70nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent