BDBM510972 5-(2,4-difluorophenyl)-N- [(4s)-6-({5-carbamoyl-1- methyl-1H-pyrazolo[3,4- b]pyridin-6- yl}oxy)spiro[3.3]heptan-2- yl]-1,3,4-thiadiazole-2- carboxamide::US11078197, Example 151::US11673886, Example 151

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4nnc(s4)-c4ccc(F)cc4F)C3)nc12

InChI Key InChIKey=JTLIWBMYQJQRJB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510972   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510972(5-(2,4-difluorophenyl)-N- [(4s)-6-({5-carbamoyl-1-...)
Affinity DataIC50: 1.36E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510972(5-(2,4-difluorophenyl)-N- [(4s)-6-({5-carbamoyl-1-...)
Affinity DataIC50: 13.6nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent