BDBM510942 1-(difluoromethyl)-6-(2- hydroxy-2- methylpropoxy)-N-[(4s)-6- ({3- carbamoylpyrazolo[1,5- a]pyridin-2- yl}oxy)spiro[3.3]heptan-2- yl]-1H-indazole-3- carboxamide::US11078197, Example 121::US11673886, Example 121

SMILES CC(C)(O)COc1ccc2c(nn(C(F)F)c2c1)C(=O)N[C@H]1C[C@]2(C1)C[C@@H](C2)Oc1nn2ccccc2c1C(N)=O

InChI Key InChIKey=FAYIBDAKMNDEFB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510942   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510942(1-(difluoromethyl)-6-(2- hydroxy-2- methylpropoxy)...)
Affinity DataIC50: 1.83E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
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TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510942(1-(difluoromethyl)-6-(2- hydroxy-2- methylpropoxy)...)
Affinity DataIC50: 18.3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent