BDBM510931 2-cyclopropyl-4- {[{aR)-6-[4-(2- methylpropyl)-2,5- dioxoimidazolidin-1- yl]spiro[3.3]heptan- 2-yl]oxy}-1,3- thiazole-5- carboxamide, diastereomer 1::US11078197, Example 110::US11078197, Example 111::US11673886, Example 111

SMILES CC(C)CC1NC(=O)N([C@H]2C[C@@]3(C[C@@H](C3)Oc3nc(sc3C(N)=O)C3CC3)C2)C1=O

InChI Key InChIKey=AKKRYYASMPIOBB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 510931   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510931(US11078197, Example 110 | 2-cyclopropyl-4- {[{aR)-...)
Affinity DataIC50: 1.22E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510931(US11078197, Example 110 | 2-cyclopropyl-4- {[{aR)-...)
Affinity DataIC50: 1.06E+5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510931(US11078197, Example 110 | 2-cyclopropyl-4- {[{aR)-...)
Affinity DataIC50: 27.4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510931(US11078197, Example 110 | 2-cyclopropyl-4- {[{aR)-...)
Affinity DataIC50: 12.2nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510931(US11078197, Example 110 | 2-cyclopropyl-4- {[{aR)-...)
Affinity DataIC50: 106nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent