BDBM510904 5-{[(aR)-6-(3- cyanobenzamido) spiro[3.3]heptan-2- yl]oxy}thieno[3,2- b]pyridine-6- carboxamide::US11078197, Example 83::US11673886, Example 83

SMILES NC(=O)c1cc2sccc2nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2cccc(c2)C#N)C1

InChI Key InChIKey=CZQDFHDDRBGDMR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510904   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510904(5-{[(aR)-6-(3- cyanobenzamido) spiro[3.3]heptan-2-...)
Affinity DataIC50: 9.70E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510904(5-{[(aR)-6-(3- cyanobenzamido) spiro[3.3]heptan-2-...)
Affinity DataIC50: 9.70nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent