BDBM510903 N-[6-({3-carbamoyl- 5H,7H,8H- pyrano[4,3- b]pyridin-2- yl}oxy)spiro[3.3] heptan-2-yl]-6-(2- hydroxy-2- methylpropoxy) pyrazolo[1,5-a]pyridine- 3-carboxamide::US11078197, Example 82::US11673886, Example 82

SMILES CC(C)(O)COc1ccc2c(cnn2c1)C(=O)NC1CC2(C1)CC(C2)Oc1nc2CCOCc2cc1C(N)=O

InChI Key InChIKey=IDTKVHSBKWDWMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510903   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510903(N-[6-({3-carbamoyl- 5H,7H,8H- pyrano[4,3- b]pyridi...)
Affinity DataIC50: 2.00E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510903(N-[6-({3-carbamoyl- 5H,7H,8H- pyrano[4,3- b]pyridi...)
Affinity DataIC50: 20nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent