BDBM510882 1-cyclopropyl-3- {[(aR)-6-[6-(6- fluoropyridin-3-yl)- 3-(trifluoromethyl) imidazo[1,5-a]pyridine- 1-amido]spiro[3.3] heptan-2-yl]oxy}-1H- pyrazole-4- carboxamide::US11078197, Example 59::US11673886, Example 59

SMILES NC(=O)c1cn(nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2nc(n3cc(ccc23)-c2ccc(F)nc2)C(F)(F)F)C1)C1CC1

InChI Key InChIKey=RTHCYXLBXZTCHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510882   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510882(1-cyclopropyl-3- {[(aR)-6-[6-(6- fluoropyridin-3-y...)
Affinity DataIC50: 5.30E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
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TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510882(1-cyclopropyl-3- {[(aR)-6-[6-(6- fluoropyridin-3-y...)
Affinity DataIC50: 5.30nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent