BDBM510876 1-(difluoromethyl)- 3-{[(aR)-6-[6- (2,2,2-trifluoroethoxy) pyrazolo[1,5-a]pyridine- 3-amido]spiro[3.3] heptan-2-yl]oxy}-1H- pyrazole-4- carboxamide::US11078197, Example 53::US11673886, Example 53

SMILES NC(=O)c1cn(nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2cnn3cc(OCC(F)(F)F)ccc23)C1)C(F)F

InChI Key InChIKey=FCBRHILQEZGZSA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510876   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510876(1-(difluoromethyl)- 3-{[(aR)-6-[6- (2,2,2-trifluor...)
Affinity DataIC50: 2.20E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
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TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510876(1-(difluoromethyl)- 3-{[(aR)-6-[6- (2,2,2-trifluor...)
Affinity DataIC50: 22nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent