BDBM510857 4-[((aR)-6-{6-[3- (chloromethyl)-3- (hydroxymethyl)azetidin- 1-yl]pyrazolo[1,5- a]pyridine-3- amido}spiro[3.3] heptan-2-yl)oxy]-2- methyl-1,3-thiazole- 5-carboxamide::US11078197, Example 34::US11673886, Example 34

SMILES Cc1nc(O[C@H]2C[C@@]3(C[C@@H](C3)NC(=O)c3cnn4cc(ccc34)N3CC(CO)(CCl)C3)C2)c(s1)C(N)=O

InChI Key InChIKey=CXULVCQFYYUEIA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510857   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510857(4-[((aR)-6-{6-[3- (chloromethyl)-3- (hydroxymethyl...)
Affinity DataIC50: 1.72E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510857(4-[((aR)-6-{6-[3- (chloromethyl)-3- (hydroxymethyl...)
Affinity DataIC50: 17.2nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent