BDBM510827 US11078197, Example 4::US11673886, Example 4

SMILES Cn1cc(C(N)=O)c(OC2C[C@]3(C[C@@H](C3)NC(=O)c3cnn4cc(OCCC(F)(F)F)ccc34)C2)n1

InChI Key InChIKey=HSPQRNGHMRRPIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510827   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510827(US11078197, Example 4 | US11673886, Example 4)
Affinity DataIC50: 2.01E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510827(US11078197, Example 4 | US11673886, Example 4)
Affinity DataIC50: 20.1nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent