BDBM510722 1-(4-((3S,4R)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((6-fluoro-[1,1'-biphenyl]-3-yl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 176

SMILES CC(=O)N1CCN(CC1)C(=O)N1C[C@@H]([C@H](C1)S(=O)(=O)c1ccc(F)c(c1)-c1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=JMJNLOQXWFXKDO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 510722   

TargetNuclear receptor ROR-gamma [262-507](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510722(1-(4-((3S,4R)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,...)
Affinity DataIC50: 84nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent