BDBM5107 N-(5-tert-Butyl-4-methyl-1,3-thiazol-2-yl)-3-nitrobenzenesulfonamide::N-[(2Z)-5-tert-butyl-4-methyl-2,3-dihydro-1,3-thiazol-2-ylidene]-3-nitrobenzene-1-sulfonamide::thiazolidenebenzenesulfonamide deriv. 4

SMILES Cc1[nH+]c([N-]S(=O)(=O)c2cccc(c2)[N+]([O-])=O)sc1C(C)(C)C

InChI Key InChIKey=AQQSZNHAFBUILD-UHFFFAOYSA-O

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5107   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5107(N-(5-tert-Butyl-4-methyl-1,3-thiazol-2-yl)-3-nitro...)
Affinity DataIC50: 370nMpH: 8.4 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5107(N-(5-tert-Butyl-4-methyl-1,3-thiazol-2-yl)-3-nitro...)
Affinity DataIC50: 470nMpH: 8.4 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5107(N-(5-tert-Butyl-4-methyl-1,3-thiazol-2-yl)-3-nitro...)
Affinity DataIC50: 3.20E+4nMpH: 8.4 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed